Personal profile

Training experience

2000PhD in Biochemistry at "Sapienza" University of Rome, Rome, Italy
1995Laurea in Biological Sciences at "Sapienza" University of Rome, Rome, Italy. Thesis on "Human hemoglobin mutants" awarded with 110/110 cum laude

Disciplinary Classification

BIO/10

Training experience

2000PhD in Biochemistry at "Sapienza" University of Rome, Rome, Italy
1995Laurea in Biological Sciences at "Sapienza" University of Rome, Rome, Italy. Thesis on "Human hemoglobin mutants" awarded with 110/110 cum laude

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Thioredoxin-Disulfide Reductase Chemical Compounds

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Research Output 2002 2016

  • 1070 Citations
  • 17 h-Index
  • 30 Article
  • 3 Conference contribution
  • 1 Paper

Pichia pastoris Fep1 is a [2Fe-2S] protein with a Zn finger that displays an unusual oxygen-dependent role in cluster binding

MIELE, A. E., MIELE, R., CUTONE, A., BONACCORSI DI PATTI, M. C., Battistoni, A., Giorgi, A., Howes, B. D., Smulevich, G. & Musci, G. 2016 In : Scientific Reports. 6

Research output: Research - peer-reviewArticle

Cysteine
Oxygen
Proteins
Zinc
Iron
3 Citations

Uncovering new structural insights for antimalarial activity from cost-effective aculeatin-like derivatives

MIELE, A. E., Wong, Y-S., Maynadier, M., Boumis, G., Vial, H., Lespinasse, M-A., Winkler, M. & Wein, S. 2015 In : Organic and Biomolecular Chemistry. 13, 7, p. 2064-2077 14 p.

Research output: Research - peer-reviewArticle

Antimalarials
Scaffolds
Derivatives
Costs
Plasmodium falciparum
2 Citations

Selenocysteine robustness versus cysteine versatility: A hypothesis on the evolution of the moonlighting behaviour of peroxiredoxins

BELLELLI, A., MIELE, A. E., Angelucci, F., Boumis, G., Desiato, G. & Saccoccia, F. 2014 In : Biochemical Society Transactions. 42, 6, p. 1768-1772 5 p.

Research output: Research - peer-reviewArticle

Selenocysteine
Peroxiredoxins
Peroxides
Cysteine
Oxidation-Reduction
24 Citations

Thioredoxin reductase and its inhibitors

BELLELLI, A., MIELE, A. E., CAROTTI, D., Saccoccia, F., Angelucci, F., Boumis, G. & Desiato, G. 2014 In : Current Protein and Peptide Science. 15, 6, p. 621-646 26 p.

Research output: Research - peer-reviewArticle

Thioredoxin-Disulfide Reductase
Thioredoxins
Enzymes
Physiological Phenomena
Xenobiotics
4 Citations

Hemoglobin allostery: New views on old players

BELLELLI, A., MIELE, A. E. & Brunori, M. 2013 In : Journal of Molecular Biology. 425, 9, p. 1515-1526 12 p.

Research output: Research - peer-reviewArticle

Hemoglobins
Heme
Proteins
Allosteric Regulation
Trout